Pentamidine is a positively charged aromatic diamidine:




Pentamidine isethionate is marketed for injection (pentam 300) or for use as an aerosol (nebu-pent). One milligram of pentamidine base is equivalent to 1.74 mg of the pentamidine isethion-ate. The isethionate salt is highly water soluble. Solutions should be used promptly because pentamidine is unstable in solution.

ANTIPROTOZOAL EFFECTS The diamidines are effective for the treatment of T. brucei gambiense sleeping sickness but not T. brucei rhodesiense or T. cruzi infections. They also are useful for treating antimony-resistant leishmania.

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