Pharmacokinetics

Isoflurane has a blood:gas partition coefficient substantially lower than that of halothane or enflurane (Table 13-1). Consequently, induction with isoflurane and recovery from isoflurane are relatively rapid. More than 99% of inhaled isoflurane is excreted unchanged via the lungs. Isoflurane does not appear to be a mutagen, teratogen, or carcinogen.

CLINICAL USE Isoflurane is typically used for maintenance of anesthesia after induction with other agents because of its pungent odor, but induction of anesthesia can be achieved in <10 minutes with an inhaled concentration of 3% isoflurane in O2; this concentration is reduced to 1-2% for maintenance of anesthesia. Use of drugs (e.g., opioids, nitrous oxide) reduces the concentration of isoflurane required for surgical anesthesia.

Was this article helpful?

0 0
Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment