Pharmacokinetics

Isoflurane has a blood:gas partition coefficient substantially lower than that of halothane or enflurane (Table 13-1). Consequently, induction with isoflurane and recovery from isoflurane are relatively rapid. More than 99% of inhaled isoflurane is excreted unchanged via the lungs. Isoflurane does not appear to be a mutagen, teratogen, or carcinogen.

CLINICAL USE Isoflurane is typically used for maintenance of anesthesia after induction with other agents because of its pungent odor, but induction of anesthesia can be achieved in <10 minutes with an inhaled concentration of 3% isoflurane in O2; this concentration is reduced to 1-2% for maintenance of anesthesia. Use of drugs (e.g., opioids, nitrous oxide) reduces the concentration of isoflurane required for surgical anesthesia.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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