The onset and duration of an induction dose of ketamine (Table 13-2) are determined by the same distribution/redistribution mechanism operant for all the other parenteral anesthetics.
Ketamine is hepatically metabolized to norketamine, which has reduced CNS activity; norke-tamine is further metabolized and excreted in urine and bile. Ketamine has a large volume of distribution and rapid clearance that make it suitable for continuous infusion without the drastic lengthening in duration of action seen with thiopental (Table 13-2 and Figure 13-2).
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