Pharmacokinetics And Metabolism

The onset and duration of an induction dose of ketamine (Table 13-2) are determined by the same distribution/redistribution mechanism operant for all the other parenteral anesthetics.

Ketamine is hepatically metabolized to norketamine, which has reduced CNS activity; norke-tamine is further metabolized and excreted in urine and bile. Ketamine has a large volume of distribution and rapid clearance that make it suitable for continuous infusion without the drastic lengthening in duration of action seen with thiopental (Table 13-2 and Figure 13-2).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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