Pharmacokinetics And Metabolism

The onset and duration of an induction dose of ketamine (Table 13-2) are determined by the same distribution/redistribution mechanism operant for all the other parenteral anesthetics.

Ketamine is hepatically metabolized to norketamine, which has reduced CNS activity; norke-tamine is further metabolized and excreted in urine and bile. Ketamine has a large volume of distribution and rapid clearance that make it suitable for continuous infusion without the drastic lengthening in duration of action seen with thiopental (Table 13-2 and Figure 13-2).

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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