Pharmacokinetics And Metabolism

Oral acetaminophen has excellent bioavailability. Peak plasma concentrations occur within 30-60 minutes and the t122 in plasma is -2 hours. Binding of the drug to plasma proteins is less than with other NSAIDs. Some 90-100% of the drug may be recovered in the urine within the first day at therapeutic dosing, primarily after hepatic conjugation with glucuronic acid (-60%), sulfuric acid (-35%), or cysteine (-3%); small amounts of hydroxylated and deacetylated metabolites also have been detected (Table 26-1). Children have less capacity for glucuronidation of the drug than do adults. A small proportion of acetaminophen undergoes CYP-mediated N-hydroxylation to form N-acetyl-p-benzoquinoneimine (NAPQI), a highly reactive intermediate (see below).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment