Pharmacokinetics And Metabolism

The pharmacokinetics of propofol are summarized in Table 13-2. Propofol's duration after infusion (shorter than that of thiopental) can be explained by its very high clearance, coupled with the slow diffusion of drug from the peripheral to the central compartment. The rapid clearance of propofol explains its less severe hangover compared with barbiturates and may allow for a more rapid discharge from the recovery room. Propofol is metabolized in the liver to less active metabolites that are renally excreted Propofol is highly protein bound, and its pharmacokinetics, like those of the barbiturates, may be affected by conditions that alter serum protein levels.

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