Pharmacokinetics

Consistent with its blood: gas partition coefficient, induction of anesthesia and recovery from enflurane are relatively slow (Table 13-1). Enflurane is metabolized to a modest extent (2-8% of absorbed enflurane) by hepatic CYP2E1. Fluoride ions are a by-product of enflurane metabolism, but plasma fluoride levels are low and nontoxic. Patients taking isoniazid exhibit enhanced metabolism of enflurane with a consequent elevation of serum fluoride.

CLINICAL USE Enflurane is primarily utilized for maintenance rather than induction of anesthesia, although surgical anesthesia can be induced in <10 minutes with an inhaled concentration of 4% in oxygen. Anesthesia can be maintained with concentrations from 1.5% to 3%. Concentrations required to produce anesthesia are reduced when enflurane is coadministered with nitrous oxide or opioids.

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment