Pharmacokinetics

The H2 receptor antagonists are rapidly absorbed after oral administration, with peak serum concentrations within 1-3 hours. Therapeutic levels are achieved rapidly after intravenous dosing and are maintained for 4-5 hours (cimetidine), 6-8 hours (ranitidine), or 10-12 hours (famotidine). Unlike proton pump inhibitors, only a small percentage of H2 receptor antagonists are protein-bound. Liver disease per se is not an indication for dose adjustment. The kidneys excrete these drugs and their metabolites by filtration and renal tubular secretion, and it is important to reduce doses of H2 receptor antagonists in patients with decreased creatinine clearance. Neither hemodialysis nor peritoneal dialysis clears significant amounts of the drugs.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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