Pharmacological Properties

Table 9-1 summarizes the pharmacological properties of various neuromuscular blocking agents. The anatomy, physiology, and pharmacology of the motor end plate are shown in Figure 9-3.

SKELETAL MUSCLE Competitive antagonists competitively block the binding of ACh to the nicotinic ACh receptor at the end plate. The depolarizing agents, such as succinylcholine, act by a different mechanism: initially, they depolarize the membrane by opening channels in the same manner as ACh. However, they persist for longer durations at the neuromuscular junction because of their resistance to AChE. The depolarization is thus longer-lasting, resulting in a brief period of repetitive excitation (fasciculations), followed by block of neuromuscular transmission (and flaccid paralysis). Paralysis occurs because released ACh binds to receptors on an already depolarized end

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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