Pharmacological Properties

Fentanyl is ~100 times more potent than morphine, and sufentanil is ~1000 times more potent than morphine. These drugs are most commonly administered intravenously, although both also are commonly administered epidurally and intrathecally for acute postoperative and chronic pain management. Fentanyl and sufentanil are far more lipid soluble than morphine, greatly reducing the risk of delayed respiratory depression from rostral spread of intraspinally administered narcotic to respiratory centers. The time to peak analgesic effect after intravenous administration of fentanyl and sufentanil is less than that for morphine and meperidine, with peak analgesia being reached after 5 minutes, as opposed to 15 minutes. Recovery from analgesic effects also occurs more quickly. However, with larger doses or prolonged infusions, the effects of these drugs become more lasting, with durations of action becoming similar to those of longer-acting opioids (see below).

Fentanyl and its derivatives decrease the heart rate and can mildly decrease blood pressure. However, these drugs do not release histamine and generally provide a marked degree of cardiovascular stability. Direct depressant effects on the myocardium are minimal. For this reason, high doses of fentanyl or sufentanil are commonly used as the primary anesthetic for patients undergoing cardiovascular surgery or for patients with poor cardiac function. Fentanyl and sufentanil undergo hepatic metabolism and renal excretion. Therefore, with the use of higher doses or prolonged infusions, fentanyl and sufentanil become longer acting.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment