Prilocaine (citanest) is an intermediate-acting amino amide that is pharmacologically similar to lidocaine, except that it causes little vasodilation and thus can be used without a vasoconstrictor if desired, and its increased volume of distribution reduces its cNs toxicity, making it suitable for intravenous regional blocks (see below). As a consequence of the metabolism of the aromatic ring to o-toluidine, prilocaine can cause methehemoglobinemia. Development of methemoglobinemia is dose dependent, usually appearing after a dose of 8 mg/kg. Methemoglobinemia usually is not a problem in healthy adults but is more common in neonates due to decreased resistance of fetal hemoglobin to oxidant stresses and the immaturity of enzymes that convert methemoglobin back to the ferrous state.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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