Prilocaine (citanest) is an intermediate-acting amino amide that is pharmacologically similar to lidocaine, except that it causes little vasodilation and thus can be used without a vasoconstrictor if desired, and its increased volume of distribution reduces its cNs toxicity, making it suitable for intravenous regional blocks (see below). As a consequence of the metabolism of the aromatic ring to o-toluidine, prilocaine can cause methehemoglobinemia. Development of methemoglobinemia is dose dependent, usually appearing after a dose of 8 mg/kg. Methemoglobinemia usually is not a problem in healthy adults but is more common in neonates due to decreased resistance of fetal hemoglobin to oxidant stresses and the immaturity of enzymes that convert methemoglobin back to the ferrous state.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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