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Q fever, tetracyclines for, 764 QT prolongation antiarrhythmic drugs and, 579-580/ antidepressants and, 294 antipsychotics and, 310 apomorphine and, 343 arsenic trioxide and, 894 ethanol and, 376 with polymorphic ventricular tachycardia. See Torsades de pointes quinidine and, 601 quinolones and, 727 thiazide diuretics with quinidine and, 489 Quazepam chemistry, 264/ dosage, 268/ elimination, 267 therapeutic uses, 268/ QUESTRAN (cholestyramine), 642 QUESTRAN LIGHT (cholestyramine),

642 Quetiapine dose and dosage forms, 309/ excretion, 307/ in Huntington's disease, 346 serotonin antagonism in, 200 side effects, 309/ Quinacrine, 1085 Quinagolide, 974 Quinapril absorption, metabolism, and excretion, 521 dosage, 521

for heart failure, 566-567 for hypertension, 554 Quinazoline a antagonists, 172-174 Quinethazone, 491/ Quinidine, 601-602 adverse effects, 601 for cardiac arrhythmias, 587/, 594/, 601 dosage, 594/ interactions, 602

with amiodarone, 596 with Ca2+ channel antagonists, 554

with digoxin, 597 with itraconazole, 803/ with quinolones, 727 with rifabutin, 794 with rifampin, 787 with telithromycin, 777 with thiazide diuretics, 489

for malaria, 663/, 6671, 674 pharmacogenetics, 6 pharmacokinetics, 594/, 601-602 pharmacological effects, 584, 587/, 601

Quinine, 674-676

absorption, fate, and excretion, 674 adverse effects, 675 antimalaria effects, 663/, 674 for babesiosis, 683 chemistry, 672/ contraindications, 675-676 interactions, 676

with mefloquine, 677 for malaria, 667/, 675 pharmacological effects, 674 skeletal muscle effects, 674 therapeutic uses, 675 toxicity, 675 Quinolines, 671-678. See also specific agents Quinolone(s), 722-726

absorption, fate, and excretion, 725 adverse effects, 726-727 for anthrax, 726

antibacterial spectrum, 722, 725 for bone, joint, and soft tissue infections, 726 chemistry, 722, 723-724/ for gastrointestinal infections, 726

interaction with sucralfate, 627 mechanisms of action, 722, 725/ for mycobacterial infections, 785/, 789

resistance to, 725 for respiratory infections, 726 therapeutic uses, 725-726 for urinary tract infections, 725 Quinupristin/dalfopristin absorption, distribution, and excretion, 779 adverse effects, 779 antibacterial activity, 779 mechanisms of action, 779 resistance to, 779 therapeutic uses, 779 QUlXlN(levofloxacin), 1100/

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