Renin And Angiotensin

OVERVIEW Angiotensin II (Angll), the most active angiotensin peptide, is derived from angiotensinogen via two proteolytic steps. First, renin, an enzyme released from the kidneys, cleaves the decapeptide angiotensin I (AngI) from the amino terminus of angiotensinogen (renin substrate). Angiotensin-converting enzyme (ACE) then removes the carboxy-terminal dipeptide of AngI to produce the octapeptide AngII. AngII is degraded subsequently by further proteolysis (see summary, Figure 30-1). AngII acts by binding to two GPCRs (see below).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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