Renin And Angiotensin

OVERVIEW Angiotensin II (Angll), the most active angiotensin peptide, is derived from angiotensinogen via two proteolytic steps. First, renin, an enzyme released from the kidneys, cleaves the decapeptide angiotensin I (AngI) from the amino terminus of angiotensinogen (renin substrate). Angiotensin-converting enzyme (ACE) then removes the carboxy-terminal dipeptide of AngI to produce the octapeptide AngII. AngII is degraded subsequently by further proteolysis (see summary, Figure 30-1). AngII acts by binding to two GPCRs (see below).

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