Respiratory Effects

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Acting at b2 receptors on bronchial smooth muscle, Epi is a powerful bronchodilator, especially when bronchial muscle is contracted because of disease or in response to drugs or various auta-coids. Beneficial effects of Epi in asthma also may arise from b2-mediated inhibition of antigen-induced release of inflammatory mediators from mast cells, and to a lesser extent from an a adrenergic effect to diminish bronchial secretions and congestion within the mucosa. Other drugs, such as glucocorticoids and leukotriene-receptor antagonists, have more profound antiinflammatory effects in asthma (see Chapter 27).

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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