Saturable Protein Binding

As the concentration of drug increases, the unbound fraction eventually also must increase (as all binding sites become saturated when drug concentrations in plasma are in the range of 10s to 100s of mg/mL). For a drug that is metabolized by the liver with a low intrinsic clearance-extraction ratio, saturation of plasma-protein binding will cause both V and CL to increase; t1/2 thus may remain constant (Equation 1-9). For such a drug, Css will not increase linearly as the rate of drug administration is increased. For drugs that are cleared with high intrinsic clearance-extraction ratios, Css can remain linearly proportional to the rate of drug administration. In this case, hepatic clearance will not change, and the increase in V will increase the t1/2 by reducing the fraction of the total drug in the body that is delivered to the liver per unit of time. Most drugs fall between these two extremes.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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