State Dependent Ion Channel Block

A key concept is that ion channel-blocking drugs bind to specific sites on ion channel proteins to modify function (e.g., decrease current) and that the affinity of the ion channel protein for the drug on its target site varies as the ion channel protein shuttles among functional conformations (or ion

A Mechanistic Approach to Antiarrhythmic Therapy


Common Mechanism

Acute Therapy"

Chronic Therapy"

Premature atrial, nodal, or


None indicated

None indicated

ventricular depolarizations

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