State Dependent Ion Channel Block

A key concept is that ion channel-blocking drugs bind to specific sites on ion channel proteins to modify function (e.g., decrease current) and that the affinity of the ion channel protein for the drug on its target site varies as the ion channel protein shuttles among functional conformations (or ion

A Mechanistic Approach to Antiarrhythmic Therapy


Common Mechanism

Acute Therapy"

Chronic Therapy"

Premature atrial, nodal, or


None indicated

None indicated

ventricular depolarizations

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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