State Dependent Ion Channel Block

A key concept is that ion channel-blocking drugs bind to specific sites on ion channel proteins to modify function (e.g., decrease current) and that the affinity of the ion channel protein for the drug on its target site varies as the ion channel protein shuttles among functional conformations (or ion

A Mechanistic Approach to Antiarrhythmic Therapy


Common Mechanism

Acute Therapy"

Chronic Therapy"

Premature atrial, nodal, or


None indicated

None indicated

ventricular depolarizations

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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