Streptomycin is used for the treatment of certain unusual infections usually in combination with other antimicrobial agents. Because it is less active than other members of the class against aerobic gram-negative rods, it has fallen into disuse. Streptomycin may be administered by deep intramuscular injection or intravenously. The dose of streptomycin is 15 mg/kg/day for patients with creatinine clearances above 80 mL/min. It typically is administered as a 1000-mg single daily dose or 500 mg twice daily. The daily dose should be reduced in proportion to creatinine clearance for creatinine clearances >30 mL/min (Table 45-1).
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