Sulfonamides And Sulfones

The sulfonamides and sulfones have antimalarial activity. The sulfonamides are used together with pyrimethamine and often in addition to quinine to treat chloroquine-resistant P. falciparum malaria, especially in parts of Africa. The sulfonamides and sulfones are slow-acting blood schizontocides that are more active against P. falciparum than P. vivax. The sulfonamides are used together with inhibitors of parasite dihydrofolate reductase to enhance their antiplasmodial action. The synergistic "antifolate" combination of sulfadoxine, a long-acting sulfonamide, with pyrimethamine (fansidar) is used to treat malarial attacks. The sulfone dapsone given with the biguanide chlorproguanil also has been effective for therapy of chloroquine-resistant P. falciparum malaria.

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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