Sulfonamides And Sulfones

The sulfonamides and sulfones have antimalarial activity. The sulfonamides are used together with pyrimethamine and often in addition to quinine to treat chloroquine-resistant P. falciparum malaria, especially in parts of Africa. The sulfonamides and sulfones are slow-acting blood schizontocides that are more active against P. falciparum than P. vivax. The sulfonamides are used together with inhibitors of parasite dihydrofolate reductase to enhance their antiplasmodial action. The synergistic "antifolate" combination of sulfadoxine, a long-acting sulfonamide, with pyrimethamine (fansidar) is used to treat malarial attacks. The sulfone dapsone given with the biguanide chlorproguanil also has been effective for therapy of chloroquine-resistant P. falciparum malaria.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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