Because of the shortcomings of cohort and case-control studies and meta-analyses, additional approaches are needed. Spontaneous reporting of adverse reactions has proven to be an effective way to generate an early signal that a drug may cause an adverse event. In the past few years, considerable effort has gone into improving the reporting system in the U.S., which is now called MedWatch. Still, the voluntary reporting system in the U.S. is deficient compared with the legally mandated systems of many other nations.
For a complete Bibliographical listing see Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th ed., or Goodman & Gilman Online at www.accessmedicine.com.
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