The Nicotinic Acetylcholine Receptor

ACh interacts with the nicotinic ACh receptor to initiate an end-plate potential (EPP) in muscle or an excitatory postsynaptic potential (EPSP) in peripheral ganglia (Chapter 6). The nicotinic receptor of vertebrate skeletal muscle is a pentamer composed of 4 distinct subunits (a, ยก, g, and d) in the stoichiometric ratio of 2:1:1:1, respectively. In mature, innervated muscle end plates, the g subunit is replaced by the closely related e subunit. The nicotinic receptor is prototypical of other pen-tameric ligand-gated ion channels, which include the receptors for the inhibitory amino acids (g-aminobutyric acid [GABA] and glycine) and 5-HT3 serotonin receptors (Figure 9-1).

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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