Therapeutic Uses

Inhaled zanamivir is effective for the prevention and treatment of influenza A and B virus infections. Early zanamivir treatment (10 mg twice daily for 5 days) of febrile influenza in ambulatory adults and children >5 years old shortens the duration of illness by 1—3 days and in adults reduces by 40% the risk of lower respiratory tract complications requiring antibiotic use. Once-daily zanamivir is highly protective against community-acquired influenza illness, and when given for 10 days, protects against household transmission.

ANTIHEPATITIS AGENTS Adefovir chemistry and antiviral activity Adefovir dipivoxil (9-[2-[bis[(pivaloyloxy) methoxy]phosphinyl]methoxyl]ethyl]adenine, bis-POM PMEA) is a diester prodrug of adefovir, an acyclic phosphonate nucleotide analog of adenosine monophosphate.

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