Therapeutic Uses

Neomycin has been used widely for topical application in a variety of infections of the skin and mucous membranes, including those associated with burns, wounds, ulcers, and infected dermatoses. Such treatment does not eradicate bacteria from the lesions.

For hepatic encephalopathy, a daily dose of 4-12 g (in divided doses) by mouth is given, provided that renal function is normal. Because renal insufficiency is a complication of hepatic failure and neomycin is nephrotoxic, it is used rarely for this indication. Lactulose is a much less toxic agent and is preferred.

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