Therapeutic Uses

A major use of PBZ (dibenzyline) is in the treatment of pheochromocytoma, tumors of the adrenal medulla and sympathetic neurons that secrete enormous quantities of catecholamines. The usual result is hypertension, which may be episodic and severe. PBZ is almost always used to treat the patient in preparation for surgical removal of the tumor. The standard therapy is to initiate PBZ (at a dosage of 10 mg twice daily) 1-3 weeks before the operation, increasing the dose every other day until the desired effect on blood pressure is achieved. Therapy may be limited by postural hypotension; nasal stuffiness is another frequent adverse effect. Prolonged treatment with PBZ may be necessary in patients with inoperable or malignant pheochromocytoma; the usual daily dose is 40-120 mg given in 2-3 divided portions. Metyrosine, a competitive inhibitor of tyrosine hydroxylase, may be a useful adjuvant. Beta receptor antagonists also are used to treat pheochromocytoma, but only after the administration of an a receptor antagonist (see below).

PBZ has been used off-label to control the manifestations of autonomic hyperreflexia in patients with spinal cord transection.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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