Therapeutic Uses

Readily treatable mycotic infections include those of the hair (tinea capitis) caused by Microspo-rum canis, M. audouinii, Trichophyton schoenleinii, and T. verrucosum; "ringworm" of the glabrous skin; tinea cruris and tinea corporis caused by M. canis, T. rubrum, T. verrucosum, and Epidermophyton floccosum; and tinea of the hands (T. rubrum and T. mentagrophytes) and beard (Trichophyton species). Griseofulvin also is effective in "athlete's foot" or epidermophytosis involving the skin and nails, the vesicular form of which is most commonly due to T. mentagro-phytes and the hyperkeratotic type to T. rubrum. Topical therapy is preferred. T. rubrum and T. mentagrophytes infections may require higher-than-conventional doses. Since very high doses of griseofulvin are carcinogenic and teratogenic in animals, it should not be used systemically to treat trivial infections that respond to topical therapy. Griseofulvin is not effective in treatment of subcutaneous or deep mycoses.

The recommended daily dose of griseofulvin is 5-15 mg/kg for children and 0.5—1 g for adults. Doses of 1.5-2 g daily may be used for short periods in severe infections. Best results are obtained when the daily dose is divided and given at 6-hour intervals, although the drug often is given twice per day. Treatment must be continued until infected tissue is replaced by normal hair, skin, or nails, which requires 1 month for scalp and hair ringworm, 6-9 months for fingernails, and at least a year for toenails.

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