Ethosuximide is effective against absence seizures but not tonic-clonic seizures. An initial daily dose of 250 mg in children (3-6 years old) and 500 mg in older children and adults is increased by 250-mg increments at weekly intervals until seizures are adequately controlled or toxicity intervenes. Divided dosage is required occasionally to diminish nausea or drowsiness. The usual maintenance dose is 20 mg/kg/day. Use caution if the daily dose exceeds 1500 mg in adults or 750—1000 mg in children. The use of ethosuximide is discussed further below.
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