Toxicity Adverse Effects And Contraindications

Epi may cause restlessness, throbbing headache, tremor, and palpitations; these effects rapidly subside with rest, quiet, recumbency, and reassurance. More serious reactions include cerebral hemorrhage and cardiac arrhythmias. The use of large doses or the accidental, rapid intravenous injection of Epi may result in cerebral hemorrhage from the sharp rise in blood pressure. Ventricular arrhythmias may follow the drug's administration. Epi may induce angina in patients with coronary artery disease. Use of Epi generally is contraindicated in patients receiving nonselective b receptor—blocking drugs, since its unopposed actions on vascular a1 receptors may lead to severe hypertension and cerebral hemorrhage.

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