Transdermal Absorption

Absorption of drugs able to penetrate the intact skin is dependent on the surface area over which they are applied and their lipid solubility (see Chapter 63). The dermis is freely permeable to many solutes; consequently, systemic absorption of drugs occurs much more readily through inflamed, abraded, burned, or denuded skin. Unwanted effects can be produced by absorption through the skin of highly lipid-soluble substances (e.g., a lipid-soluble insecticide in an organic solvent). Transdermal absorption can be enhanced by suspending the drug in an oily vehicle and rubbing the resulting preparation into the skin. Hydration of the skin with an occlusive dressing may facilitate absorption.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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