Uses In Ophthalmology

Effects limited to the eye are obtained by local administration of muscarinic receptor antagonists to produce mydriasis and cycloplegia. Cycloplegia is not attainable without mydriasis and requires higher concentrations or more prolonged application of a given agent. In instances in which complete cycloplegia is required, more effective agents such as atropine or scopolamine are preferred to drugs such as cyclopentolate and tropicamide. Homatropine hydrobromide (isopto homatropine, others), a semisynthetic derivative of atropine (Figure 7-2) cyclopentolate hydrochloride (cyclogyl, others), and tropicamide (mydriacyl, others) are preferred to topical atropine or scopolamine because of their shorter duration of action (see Chapter 63).

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