Optimally, weight loss is achieved by a gradual increase in energy expenditure from exercise combined with dieting to decrease the caloric intake. Amphetamine promotes weight loss by suppressing appetite rather than by increasing energy expenditure. Other anorexic drugs include methamphetamine, dextroamphetamine, phentermine, benzphetamine, phendimetrazine, phen-metrazine, diethylpropion, mazindol, phenylpropanolamine, and sibutramine (a mixed adrenergic/serotonergic drug). These agents may be effective adjuncts in the treatment of obesity but they all present significant risk of adverse effects (see above). Available evidence does not support the isolated use of these drugs in the absence of a more comprehensive program that stresses exercise and diet modification.
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