Yohimbine (yocon), a competitive a2 antagonist, is an indolealkylamine alkaloid found in the bark of the tree Pausinystalia yohimbe and in Rauwolfia root; structurally, yohimbine resembles reserpine.

Yohimbine readily enters the CNS, where it acts to increase blood pressure and heart rate; it also enhances motor activity and produces tremors. Yohimbine also is an antagonist of 5-HT. In the past, yohimbine was used to treat male sexual dysfunction, although efficacy never was clearly demonstrated; yohimbine also may be useful for diabetic neuropathy and in the treatment of postural hypotension.

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