Caveats to BTSC

With the surge in interest in CSC and BTSC, some confusion regarding methods and definitions has arisen, risking assigning properties to a heterogeneous population ofcells and leading to erroneous characterization Some concerns for the current CSC hypothesis remain (Fig. 3).17 BTSCs, shown to be tumor-initiating are not independent of their site of primary culture and ultimate site of transplantation. In fact, their ability to proliferate is significantly dependent on the tumor microenvironment...

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