Stem Cell Transplantation Methods

Tran, Allen Ho and Rahul Jandial* Abstract J fust a few short years ago, we still used to think that we were born with a finite number of I irreplaceable neurons. However, in recent years, there has been increasingly persuasive evidence I that suggests that neural stem cell (NSC) maintenance and differentiation continue to take ace throughout the mammal's lifetime. Studies suggest that neural stem cells not only persist to mammalian adulthood, but also play a continuous role in...

Cancer Stem Cells Discovery and Evidence of BTSC

Approximately 150 years ago pathologists Rudolph Virchow and Julius Cohnheim suggested there were histological similarities between the developing fetus and certain cancers (such as teratocarcinomas) and that both tissues have the capacity to differentiate and proliferate. This embryonal-rest hypothesis is the historical version of today's cancer stem cell hypothesis.4 As defined at the American Association for Cancer Research workshop on cancer stem cells cancer stem cells are cells that1 self...

Caveats to BTSC

With the surge in interest in CSC and BTSC, some confusion regarding methods and definitions has arisen, risking assigning properties to a heterogeneous population ofcells and leading to erroneous characterization Some concerns for the current CSC hypothesis remain (Fig. 3).17 BTSCs, shown to be tumor-initiating are not independent of their site of primary culture and ultimate site of transplantation. In fact, their ability to proliferate is significantly dependent on the tumor microenvironment...