Contributors

Simak Ali Department of Oncology, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK, simak.ali imperial.ac.uk Alan Ashworth The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK, alan.ashworth icr.ac.uk Denise Barrow Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, UK, BarrowD cf.ac.uk Jill Bayliss Department of Internal Medicine, Division of Hematology Oncology, University...

Restoration of ERa Expression and Anti Estrogen Responses in ERaBreast Cancer Cell Lines and Primary Cultures via MAPK

Using established ERa-breast cancer cell lines, the SUM 229s which overexpress EGFR, SUM 190s which overexpress both EGFR and erbB-2, and SUM 149s which model inflammatory breast cancer and have very high levels of RhoC leading to hyperactivation of NFkB in addition to EGFR overexpression, we have recently demonstrated that inhibition of MAPK activity could result in restoration of ERa expression (Bayliss et al., 2007). In fact, inhibition of MAPK activity via the pharmacologic MEK inhibitor...

Info

Abbas, S., Bhoumik, A., Dahl, R., Vasile, S., Krajewski, S., Cosford, N.D. (2007) Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res, 13, 6769-6778. Ali, M.M., Roe, S.M., Vaughan, C.K., Meyer, P., Panaretou, B., Piper, P.W., Prodromou, C., Pearl, L.H. (2006) Crystal structure of an hsp90-nucleotide-p23 sba1 closed chaperone complex. Nature, 440, 1013-1017. Argon, Y., Simen, B.B. (1999) GRP94, an ER chaperone with protein and peptide binding properties....

T47d

Fig. 8.2 Acquired tamoxifen- and fulvestrant- resistant MCF7 and T47D cells possess a highly migratory and invasive phenotype in vitro. In the case of fulvestrant-resistant cells, their aggressive behaviour approaches that observed in the highly-metastatic MDA-MB-231 cell line addition to growing as loose, disorganised colonies in which cells appear to have partially-dissociated cell-cell contacts Fig. 8.2 Hiscox et al., 2006a, 2004a . Such cellular morphology is reportedly characteristic of a...

Are Stem Like Cells Responsible for Resistance to Therapy in Breast Cancer

O'Brien, Gillian Farnie, Sacha J. Howell and Robert B. Clarke 98 6.2 Cancer Stem-Like Cells CSCs in Breast Tumours 98 6.3 The Intrinsic Resistance of CSCs to Chemo- and Radiotherapy 100 6.4 Are Breast CSCs Resistant to Endocrine 101 6.5 The Effects of Targeted Therapies on CSCs 103 6.6 Potential of Differentiation Treatment to Re-Sensitise CSCs to Therapy 105 105 106 Abstract There is increasing evidence suggesting that some tumours originate from a stem cell population. Such...

Triciribine

Triciribine, a relatively non-toxic inhibitor, was identified from the compound screen as a potent sensitiser to tamoxifen. Triciribine is a tricyclic nucleoside that was first synthesised in 1971 Schram and Townsend 1971 and identified as a potential anticancer drug using in vitro models Schweinsberg et al. 1981 . Early clinical trials showed that low concentrations of triciribine resulted in neither response nor toxicity in advanced breast, colon, and lung cancer patients Feun et al. 1993...