Efficacy of Mycophenolate Mofetil in Patients with Diffuse Proliferative Lupus Nephritis

Source New England Journal of Medicine. 343(16) 1156-1162. October 19, 2000. Summary The combination of cyclophosphamide and prednisolone is effective for the treatment of severe lupus nephritis (kidney inflammation associated with systemic lupus erythematosus or SLE) but has serious adverse effects. This article reports on a study that investigated the efficacy of mycophenolate mofetil in patients (n 42) with proliferative lupus nephritis. The authors compared the efficacy and side effects of...

Natural History and Treatment of Lupus Nephritis

Source Seminars in Nephrology. 19(1) 2-11. January 1999. Contact Available from W.B. Saunders Company. Periodicals Department. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. (800) 654-2452. Summary Renal involvement occurs in most patients with systemic lupus erythematosus (SLE). This article discusses the natural history and treatment of lupus nephritis. Contemporary therapeutic regimens for immunosuppression and for the treatment of hypertension, hyperlipidemia, infections, and seizures have...

Bactrim for Treatment of Wegener Granulomatosis

Source Journal of Rare Diseases. 4(1) 13-14. January-February 1998. Contact Available from Dowden Publishing Company. 110 Summit Avenue, Montvale, NJ 07645. (800) 707-7040 or (202) 391-9100. Fax (201) 391-2778. Summary Wegener granulomatosis (WG) is a multisystem disease characterized by necrotizing vasculitis of the lungs and upper respiratory tract and by glomerulonephritis (inflammation of the kidney glomeruli). Perhaps 90 percent of patients treated with cyclophosphamide and prednisone...

Collagen Vascular Diseases in Critical Care An Overview

Source Care of the Critically Ill. 14(1) 29-33. January 1998. Contact Available from Stockton Press. Houndmills, Basingstoke, Hampshire RG21 6XS, UK. 44(0) 1256 329242. Fax 44(0) 1256 810526. Website Summary Although uncommon, when compared with other conditions seen in the intensive care unit (ICU), the collagen vascular diseases are life threatening, can pose diagnostic problems, and (because treatment often involves immunosuppression) can make management especially difficult in the septic...

Treatment of IgA Nephropathy

Source Seminars in Nephrology. 20(3) 277-285. May 2000. Contact Available from W.B. Saunders Company. Periodicals Department. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. (800) 654-2452. Summary IgA nephropathy (Berger's disease) is the most common primary glomerulonephritis (infection of the kidney glomeruli) worldwide and was once equated with benign recurrent hematuria (blood in the urine). This article reviews the patient care management of IgA nephropathy. Of the patient population with...

Is It Interstitial Cystitis Diagnostic Distinctions in Reduced Bladder Capacity

Source Contemporary Urology. 6(7) 13-16, 18-19, 22. July 1994. Contact Available from Medical Economics Publishing Inc. Montvale, NJ 07645. (800) 432-4570. Summary This article addresses the questions involved in the diagnostic distinctions between interstitial cystitis (IC) and other causes of reduced bladder capacity. Topics include difficulties in diagnosing IC the physiology of bladder sensation an historical review of IC clinical terminology used, including sensory urgency, motor urgency,...

Mesangioproliferative Glomerulonephritis with IgM Deposition Clinical Characteristics and Outcome

Source Renal Failure. 22(4) 445-457. 2000. Contact Available from Marcel Dekker Journals. P.O. Box 5017, Monticello, NY 127015176. (212) 696-9000. Summary The significance of IgM on immunofluorescence in renal biopsy specimens remains unclear. This article reports on a retrospective case study conducted to define the clinical features, response to therapy, and outcome of patients with mesangioproliferative glomerulonephritis (MGN) with diffuse IgM deposition. Of 1,919 native renal (kidney)...

Levamisole Therapy in Corticosteroid Dependent Nephrotic Syndrome

Source Pediatric Nephrology. 11(4) 415-417. August 1997. Contact Available from Springer-Verlag. Service Center Secaucus, 44 Hartz Way, Secaucus, NJ 07094. (201) 348-4033. Summary This article reports on a study in which the effect of prolonged treatment with levamisole was examined in 43 patients (30 boys, 13 girls) with steroid dependent nephrotic syndrome (SDNS). Levamisole is a drug that modulates phagocytic (cells that surround and digest microorganisms and cellular debris) and lymphocytic...