Benzodiazepine receptors

Caffeine at 5 to 40 mg/kg IP or 600 mg/kg in food has been shown to increase,65-67 decrease,68 or cause no change34,69 in the number of benzodiazepine receptors in the brain. Moreover, caffeine increases the binding of benzodiazepines to their receptor site in vivo,70,71 but decreases binding in cultured neurons.72 However, the number of benzodiazepine receptors is affected by stress, and different types of stress can either increase or decrease benzodiazepine receptor density. Also, the addition of caffeine to the diet did not affect benzodiazepine receptor density, while daily administration of caffeine by the intraperitoneal route, which is stressful, did.73 74 Therefore, the evidence that there is a direct affect by caffeine on benzodiazepine receptors is relatively weak. Finally, the concentrations of caffeine needed to antagonize benzodiazepine receptors is five to ten times higher than those needed to antagonize adenosine receptors.75 76 This may explain the lack of effect with the administration of caffeine in the food, but may also provide evidence that these effects are also mediated by adenosine.77

Getting to Know Anxiety

Getting to Know Anxiety

Stop Letting Anxiety Rule Your Life And Take Back The Control You Desire Right Now! You don't have to keep letting your anxiety disorder run your life. You can take back your inner power and change your life for the better starting today! In order to have control of a thing, you first must understand it. And that is what this handy little guide will help you do. Understand this illness for what it is. And, what it isn't.

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