Gcp Ii Inhibition Is A Novel Mechanism For Reduction Of Excitotoxic Glutamate

The roles of NAAG and GCP II in excitotoxic neurotransmission were investigated upon the identification of these potent and selective inhibitors of GCP II. Rats implanted with microdialysis probes were treated with either 2-PMPA or vehicle and subjected to middle cerebral artery occlusion (MCAO). Dialysates were collected up to 4 hours after occlusion and analysed for glutamate. While 2-PMPA had no significant effect on extracellular glutamate in normal, non-ischemic rats (left panel, Fig. 3), 2-PMPA signifi-

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