0.27 ± 0.01

2.7 ± 0.45


0.76 ± 0.04

7.25 ± 1.67


0.36 ± 0.03

3.9 ± 0.42


0.30 ± 0.03

3.53 ± 0.31

5.4. Altered Expression of Cell Death Influencing Genes

Serine proteinase inhibitor 2 (SPI2), Caspase-11 mRNA and interleukin 1 beta (IL-1P) converting enzyme (Caspase I) expressions (Table 1) are higher in the brain of CD mouse (54). The Spi2 induces apoptosis, gliosis and neuronal death and vacuolization (52,53). Caspase-11 is another important enzyme that induces cell death, up-regulation of this gene expression is seen in the mouse model for amyotrophic lateral sclerosis (54). Caspase-11 mediation of cell death has also been reported in the animal model for multiple sclerosis (55) and rat model of focal cerebral ischemia (56,57). These studies suggest that the high expression of Caspase-11 in the CD mouse brain is likely to induce cell death in the central nervous system. Caspase-11, which leads to the synthesis of the functional form of IL-1 P, which leads to the accumulation of the inactive pro of IL-1 p. Thus, high expression of Caspase-11 seen in the CD mouse brain may be to increase the level of active IL-1 p. Interlukin-1 P belongs to a family of proinflammatory cytokines (58). During neuronal damage or apoptosis, high level of IL-1 P is expressed (58). Thus, abnormal expression of these cell death inducing genes are at least partly, may lead to the sponginess seen in CD (59).

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