Motor Systems

The pyramidal cells of the motor cortex and their axons in the pyramidal tract stain

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for NAAG in human, but not rat. , The motor neurons of the brainstem and spinal cord are labeled for NAAG in all species examined.23, 28, 30, 34, 36, 40

NAAG is found in much of the rat's extrapyramidal motor system.24, 28 Label is seen in both cells and neuropil in the globus pallidus, entopeduncular nucleus, subthalamic nucleus, and substantia nigra. In contrast, relatively few cells in the caudate-putamen and nucleus accumbens contain NAAG.

Cells of the pontine nuclei are strongly labeled,37 as are the axons of the middle cerebellar peduncle. According to Moffett and Namboodiri,37 some cerebellar Purkinje cells are moderately positive, but most are unstained. However, Passani et al. report intense Purkinje cell labeling in both rat and human.30 Large, but not small cells in all divisions of the deep cerebellar nuclei are highly immunoreactive for NAAG.37 Additionally, many neurons of the red nucleus, both parvicellular and magnocellular

divisions, stain intensely for NAAG. , ,

Motor neurons in brainstem and spinal cord are labeled for NAAG,28, 36, 40 as are the spinal ventral roots36 and their terminals at the neuromuscular junction.41

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