NAAG and NAA in GABAergic Neuronal Groups

Unlike the partial colocalization of NAAG and GAD67 in neocortex, NAAG was expressed in virtually all GABAergic neurons in GABA projection areas such as the globus pallidus, thalamic reticular nucleus and lateral hypothalamus (Figure 8A, C, E). NAA-IR was also expressed at moderate to high levels in these cell groups (Figure 8B, D, F). One feature in common among many GABAergic projection systems containing NAAG was that NAAG was typically observed only in the cell body and basal dendrites, but not in the axons. This is in contrast to many glutamatergic projection systems containing NAAG, such as the visual projections, where NAAG is present throughout the axons and terminals.

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