3.1. NAA-Synthesis in Normal Humans

Net NAA-synthesis was readily determined in normal human subjects. As illustrated in Figure 4, 13C aspartate became rapidly enriched to steady state after about 60 minutes of 1-13C glucose administration. The much slower rate of appearance of 13C in NAA was linear over the 3 hours of this study. Net NAA-synthesis was determined to be 9.2 nano-moles/minute/gram brain in normals, about 1% of the TCA-cycle rate.

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