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1 2 Time (h) Stability of Ara-A analogs

1 2 Time (h) Stability of Ara-A analogs good stability against adenosine deaminase in blood. Fig. 3 shows the stability of 2-substituted ara-A in mice blood. Ara-A quickly dissipated in blood to form hypoxanthine arabinoside through the reaction of adenosine deaminase, but 2-substituted ara-A showed fairly high stability in mice blood. One weak point of ara-A is its instability in blood. These newly synthesized compounds are expected to show potential activity against viruses.

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