Proteases, which catalyze hydrolysis of peptide bonds in proteins or peptides, are essential enzymes in all types of organisms and, therefore, have been studied in detail by many researchers. In contrast, degradation of DKPs (2,5-diketopiperazines, 2,5-dioxopiperazines, cyclic dipeptides), which have peptide bonds in their molecules, is poorly understood in spite of their wide distribution in nature and their unique biological activities, e.g., antimicrobial, anticancer, and so on [1,2], Therefore, there is no reports on DKP-hydrolyzing enzyme except for a cyclo(Gly-Gly) hydrolase from Bacillus sp.[3].

This situation prompted us to search and investigate novel DKP-hydrolyzing enzymes. This paper describes isolation of bacteria assimilating simple DKPs and their characteristics on degradation of DKPs.

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