CB1 Activity in MaLe Reproduction Mammauan And Nonmammauan Animal Models

Riccardo Pierantoni,* Gilda Cobellis,* Rosaria Meccariello,t Giovanna Cacciola,* Rosanna Chianese,* Teresa Chioccarelli,* and Silvia Fasano*



The importance of the endocannabinoid system (ECBS) and its involvement in several physiological processes is still increasing. Since the isolation of the main active compound of Cannabis sativa, A9-THC, several lines of research have evidenced the basic roles of this signaling system mainly considering its high conservation during evolution.

In this chapter the attention is focussed on the involvement of the ECBS in the control of male reproductive aspects at both central and local levels which are both considered from a comparative point of view.

* Dipartimento di Medicina Sperimentale, Seconda Universita di Napoli, Via Costantinopoli, Napoli, Italy { Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Universita Parthenope, Napoli, Italy

Vitamins and Hormones, Volume 81 © 2009 Elsevier Inc.

ISSN 0083-6729, DOI: 10.1016/S0083-6729(09)81014-5 All rights reserved.

I. Introduction

II. Receptor Properties

III. Brain-Pituitary Axis

IV. Testis

V. Excurrent Duct System VI. Concluding Remarks References

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