Significance of stereoisomerism in determining drug action and toxicity

Pharmacy is a discipline of science that deals with various aspects of drugs. All drugs are chemical entities, and a great majority 30-50 per cent of them contain stereocentres, show stereoisomerism and exist as enantiomers. Moreover, the current trend in drug markets is a rapid increase of the sales of chiral drugs at the expense of the achiral ones. In the next few years, chiral drugs, whether enantiomerically pure or sold as a racemic mixture, will dominate drug markets. It is therefore...

Pyridine and piperidine alkaloids

Alkaloids, e.g. piperine, coniine, trigonelline, pilocarpine, nicotine and sparteine, possess a pyridine or modified pyridine heterocyclic ring system (e.g. piperidine ring). Piperine Piperine, molecular formula Ci7H19NO3, a component of black pepper (Piper nigrum), has been used in various traditional medicine preparations, and also as an insecticide. Piperine has various effects on human drug metabolizing enzymes, and is marketed under the brand name, Bioperine , as an adjunct for increasing...