Renal Parenchymal Disease and Hypertension

Source Seminars in Nephrology. 15(2) 138-151. March 1995. Contact Available from W.B. Saunders Company, Periodicals Department. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. (800) 654-2452. Summary This review article explores the interrelationship of renal parenchymal disease and hypertension. Topics include pathophysiology and pathogenesis sodium balance digitalis like factor (DLF) the renin angiotensin aldosterone system renal prostaglandins the renal kallikrein system endothelin (ET)...

Project Title Localization Of Ligand Interactions With The Sodium Pump

Principal Investigator & Institution Kaplan, Jack H. Benjamin Goldberg Professor and Head Biochem and Molecular Biology Oregon Health & Science University Portland, or 972393098 Timing Fiscal Year 2002 Project Start 01-FEB-1988 Project End 31-JAN-2005 Summary (Applicant's abstract) The objective of this work is to obtain a more complete understanding of how the sodium pump protein or Na,K-ATPase carries out its essential physiological role, the active transport of Na and K ions across the...

Acknowledgements

The collective knowledge generated from academic and applied research summarized in various references has been critical in the creation of this book which is best viewed as a comprehensive compilation and collection of information prepared by various official agencies which produce publications on digitalis. Books in this series draw from various agencies and institutions associated with the United States Department of Health and Human Services, and in particular, the Office of the Secretary...

Project Title Physiological Significance Of Nakpump Alpha Isoforms

Principal Investigator & Institution Pressley, Thomas A. Professor Physiology Texas Tech University Health Scis Center Health Sciences Center Lubbock, Tx 79430 Timing Fiscal Year 2002 Project Start 30-SEP-1994 Project End 30-JUN-2004 Summary (Applicant's Abstract) The Na,K-pump (i.e., Na,K-ATPase) is the major pharmacological receptor for cardiac glycosides such as digitalis and ouabain. It is a plasma membrane-spanning protein complex that mediates the exchange of Na+ and K+ at the expense...