Antiepileptic Drugs Anticonvulsants

• Antiepileptic drugs (AEDs) are moderately effective in the management of neuropathic pain with the number needed to treat (NNT) ranging from 1.9 to 7.1.

• AEDs may also have efficacy in conditions not considered neuropathic (fibromyalgia, orofacial myalgia).

• Gabapentin and pregabalin are of equal efficacy and should be considered as first line therapy for neuropathic pain.

• Carbamazepine and oxcarbazepine are of equal efficacy and may be considered first line therapy for trigeminal neuralgia.

• Gabapentin, pregabalin, and lamotrigine have a role in the management of central neuropathic pain.

• Safety issues vary from one AED to another, are complex, and require the full attention of the prescribing clinician.

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