• Antiepileptic drugs (AEDs) are moderately effective in the management of neuropathic pain with the number needed to treat (NNT) ranging from 1.9 to 7.1.
• AEDs may also have efficacy in conditions not considered neuropathic (fibromyalgia, orofacial myalgia).
• Gabapentin and pregabalin are of equal efficacy and should be considered as first line therapy for neuropathic pain.
• Carbamazepine and oxcarbazepine are of equal efficacy and may be considered first line therapy for trigeminal neuralgia.
• Gabapentin, pregabalin, and lamotrigine have a role in the management of central neuropathic pain.
• Safety issues vary from one AED to another, are complex, and require the full attention of the prescribing clinician.
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Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?