Are there differences between various longacting opioids or between short and longacting preparations

Chou et al., in a systematic review of 16 RCTs with

1427 patients, together with eight observational studies describing 1190 patients, address this issue.20[I]

Unfortunately, there was significant heterogeneity in the design, duration, and quality of these studies and difficulties in establishing the equivalent potency of the various opioid preparations. For the purposes of this review, a long-acting opioid was defined as a drug requiring administration no more than twice per day. Opioids studied included fentanyl, morphine, oxycodone, levorphanol, methadone, codeine, and dihydrocodeine.

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