Concepts and tools in genetics and genomics 48
Genes and chromosomes 49 Gene expression and protein synthesis - regulation of gene expression 49
DNA and human diversity 51
Complex, multifactorial disorders 53
Approaches used to conduct genetic studies 53
Expression analyses: RNA-based studies 57
Proteome analyses: protein-based studies 59
The new frontier: systems biology 60 Research-related issues unique to the study of pain alleles 60
Genetics and pain sensitivity 60 The complexities of determining genetic risk factors for chronic pain 60
Pharmacogenetics and analgesic drugs 61 Molecular biologic tools in the elucidation of pain mechanisms and drug discovery 63
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Do You Suffer From Chronic Pain? Do You Feel Like You Might Be Addicted to Pain Killers For Life? Are You Trapped on a Merry-Go-Round of Escalating Pain Tolerance That Might Eventually Mean That No Pain Killer Treats Your Condition Anymore? Have you been prescribed pain killers with dangerous side effects?