Bradley E Aouizerat And Christine A Miaskowski

Note 48

Concepts and tools in genetics and genomics 48

Introduction 48

Genes and chromosomes 49 Gene expression and protein synthesis - regulation of gene expression 49

DNA and human diversity 51

Complex, multifactorial disorders 53

Approaches used to conduct genetic studies 53

Expression analyses: RNA-based studies 57

Proteome analyses: protein-based studies 59

The new frontier: systems biology 60 Research-related issues unique to the study of pain alleles 60

Genetics and pain sensitivity 60 The complexities of determining genetic risk factors for chronic pain 60

Pharmacogenetics and analgesic drugs 61 Molecular biologic tools in the elucidation of pain mechanisms and drug discovery 63

References 63

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