The endogenous cannabinoid system has received much interest within the field of neuropathic pain due to the fact that unlike the opioid system, spinally expressed cannabinoid receptors are unaffected following nerve injury.143 In such, manipulation of the cannabinoid system has been effective in alleviating signs of neuropathic pain in animal models of neuropathic pain5,22 144145 representing a possible therapeutic advantage of cannabinoids over opioids in neuropathic pain.
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