Cytostatic Drugs

Peripheral neurotoxicity is the significant dose-limiting side effect of many chemotherapeutic drugs, including vinca alkaloids, cisplatin, and taxols. Some of these agents interfere with microtubule-based axonal transport and cause length-dependent axonal injury. Although distal paresthesiae are the initial manifestations with vinca alkaloids, there are very few sensory signs, and motor abnormalities dominate the clinical picture. It is important to be aware of these neuropathies, as there may be a unique opportunity to initiate preventive measures before the damage occurs. A neuroprotective effect of neuro-trophins has been demonstrated in tissue culture and animal models.28

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