GABA B agonists

Baclofen is used in the treatment of severe spasticity and its painful and disabling consequences. In pathophysio-logical states, in which there is an imbalance between active and passive muscles due to a failure of GABA-mediated inhibition, baclofen (a GABA-B agonist) corrects this. It is believed that the majority of GABA receptors lie in the dorsal horn and the expression of these receptors increases in pathological states; therefore, baclofen is more effective in pathological states.

Baclofen may have a primary analgesics effect; this is predominantly seen in central pain states.23

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