Table 4.2 Examples of measurements used in pain research.
human, animal, other)
Drosophila melanogaster (fruitfly) genetic studies
Understanding interindividual differences in response to pain in humans is the goal of the field
Use of inbred strains of animals for genetic studies is a proven tool in the dissection of genetic traits
Use of D. melanogaster for genetic studies is a proven tool in the dissection of genetic traits
Permits exquisite control of the cellular environment and manipulation of exposures to test hypotheses
Relatively inexpensive to mine databases for DNA, RNA, protein, and interaction data
Physiological measures of pain still require a verbal response, introducing an unknown level of imprecision Self-report measures are subjective in nature, introducing an unknown level of imprecision The study of the genetics of pain in animal models may be difficult to translate to human pain biology
The study of the genetics of pain in D. melanogaster may be difficult to translate to human pain biology
May provide limited insight into the dynamic physiologic environment in vivo Some tissue models cannot be emulated in vitro (e.g. complex interactions between cell types)
Requires an understanding of bioinformatics be useful to investigate the genetic basis for chronic pain problems that appear to occur in family members (e.g.
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